Episode 4: The Skinny On Prescription Weight Loss Injections
What To Know About Those Shots You Keep Hearing About

Weight loss injections. You know the ones. They are everywhere right now! But as you know, you can’t always trust everything you see on social media or read in headlines.
In this episode of Asking For A Friend, host Carrie Esposito is joined by Dr. Marguerite Weston, Dr. Katie D’Amato and aesthetic treatment expert Adrienne Yanich, MSN, to explore the truth behind semaglutide, tirzepatide and how these medications can impact your body and mind.
With decades of combined clinical experience, our providers have a few drinks, break down the science and share real-life patient outcomes!

But First — What Are These Shots?
Semaglutide (often sold under names like Ozempic and Wegovy) and tirzepatide (also known as Mounjaro or Zepbound) are injectable medications originally developed for type 2 diabetes that are now FDA-approved for weight loss. While slightly different in how they work, both mimic hormones that help regulate blood sugar and appetite.
Yes, they are effective. And yes, they’re generally safe when prescribed, monitored and titrated by a professional. But they’re not magic: pairing them with lifestyle changes is the real key to long-term results.
Why You Hear The Word “Compounded” So Often
Compounded medications are custom-made versions of drugs prepared by specialized pharmacies to meet individual patient needs, often when commercial options are unavailable, unaffordable or not quite the right fit. Patients who seek out compounded semaglutide tell us they do so because they find it more accessible and less expensive than name-brand versions.
Note: The compounded formulations of these medications are not FDA-approved for weight loss.
“These medications are effective! I’ve seen them change my patients’ lives in a profound way. We just really don’t think you should buy them online with no professional guidance.”
-Dr. Marguerite Weston | Functional Medicine Expert
We Cannot Stress This Enough: Not All Compounded Products Are Created Equal!
Where you get your medication matters when seeking compounded semaglutide. If you’re not getting it from a well-vetted source, you may be putting your health at risk. Always ask your provider why they recommend a specific pharmacy, how long they’ve worked with them and if there have been any supply issues in the past.
A reputable pharmacy should offer a safe, effective product that mirrors the results of the name-brand options — but only when combined with professional guidance, proper protocols, and realistic expectations.

These Shots Can Also Be Used As Strong Motivators
One of the most powerful aspects of these medications is how quickly people can start seeing results, which often gives them the confidence to keep going. They’re not a standalone solution, but they can be an amazing jumpstart when paired with nutrition support, movement and self-awareness.
“It can make you more cognizant about your body and help you get to a place where you feel comfortable going for longer walks. It helps patients begin to identify as ‘someone who moves’ — even if they never thought exercise was for them.”
-Dr. Katie | Physical Therapist
Semaglutide & Food Noise: Quieting The Anxious Internal Monologue
If you have issues with “food noise,” you know exactly what we’re talking about! It’s that constant mental chatter around food — thinking about your next meal, your cravings, your calorie counts. These medications have been shown to help reduce that noise by targeting the hunger pathways in your brain, allowing people to make more mindful choices without the mental overwhelm.
Let’s Clear The Static Together
This episode is for you if you’ve been curious about how weight loss injections work, you’re struggling with weight loss or you want to separate the real-deal supplements from the snake oil. You’ll enjoy this one, whether you’re on a health journey or just trying to understand all the noise!
About The “Asking For A Friend” Podcast
Asking For A Friend is where real questions get real answers, especially the ones you’re too embarrassed to ask out loud. Our providers share medically sound advice in a relatable, candid way that makes you feel seen and supported.
No question is off the table — because chances are, if you’re wondering about it, so is someone else!
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