3x4 Genetic Testing Columbus, Ohio
Your DNA Holds Answers to Your Health. We Help You Understand Them.
How you metabolize food. How you regulate hormones. How you process stress and the world around you. Your genes influence nearly every aspect of how your body functions. 3×4 Genetic Testing analyzes more than 150 specific genetic markers across the systems that control weight balance, metabolic health, fitness, hormone health, brain health, detoxification, digestion and more to deliver a comprehensive picture of your biological blueprint.
Clinical Insights About 3×4 Genetic Testing
- What It Is: A cheek swab that analyzes 150+ genetic markers across 36 health domains. Results are organized by “pathway,” showing how your genes work together to influence metabolism, hormones, inflammation, mood and more.
- Who It’s For: Anyone who feels like they’ve done everything right and still feels “off.” Chronic symptom sufferers, high performers looking to optimize, and anyone ready to stop guessing and start proactively working with their biology.
- Why Donaldson: The 3X4 Blueprint Report is designed to be interpreted by a trained provider, and that’s exactly what you get here. Dr. Weston and her team translate your genetic data into a personalized action plan built around your full health picture.
MORE INSIGHT
What 3x4 Genetic Testing Looks At
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01
Metabolism & Weight Management
How your genes influence appetite regulation, fat storage, blood sugar response, chronic fatigue and energy balance.
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02
Hormone Health
Genetic tendencies around hormone production, regulation and how your body responds to hormonal shifts over time.
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03
Inflammation Response
Whether your biology is predisposed toward chronic low-grade inflammation and what that means for long-term health.
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04
Nutrient Absorption & Deficiencies
How well your body processes and utilizes key vitamins, minerals and dietary inputs, including what your genes say you actually need.
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05
Brain Health & Mood
Genetic insights into stress response, memory, mood regulation and long-term cognitive performance.
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06
Fitness & Recovery
Musculoskeletal function, endurance capacity, injury predisposition and how your body responds to different types of training.
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07
Detoxification & Histamine Breakdown
How efficiently your body clears toxins through key genetic pathways, and where targeted support may help.
The Test Is Just the Beginning
Your One-On-One Follow-Up to Discuss Results
Raw genetic data is only as useful as the expertise applied to it. Every 3×4 consultation at Donaldson includes a dedicated, 60-minute appointment where a credentialed member of our functional medicine team walks through your Blueprint Report in full. They will explain what each marker means in the context of your personal health history, your symptoms and your goals.
Raw genetic data is only as useful as the expertise applied to it. Every 3×4 consultation at Donaldson includes a dedicated, 60-minute appointment where a credentialed member of our functional medicine team walks through your Blueprint Report in full. They will explain what each marker means in the context of your personal health history, your symptoms and your goals.
A Plan Built On Your Unique Health Markers
You will leave this conversation with answers and a vision of what is possible. Your follow-up appointment produces a personalized action plan spanning nutrition, movement, supplementation and lifestyle, along with recommendations for any follow-up lab work that would give us an even clearer picture alongside your genetic results.
You will leave this conversation with answers and a vision of what is possible. Your follow-up appointment produces a personalized action plan spanning nutrition, movement, supplementation and lifestyle, along with recommendations for any follow-up lab work that would give us an even clearer picture alongside your genetic results.
Providers Who Were Trained for This
Not every provider out there is equipped to interpret a 3×4 report with clinical depth. Our team has specialized training in genetic pathway analysis. This means that your results are reviewed through a lens that goes well beyond surface-level recommendations and can be used to make positive, proactive lifestyle changes.
Not every provider out there is equipped to interpret a 3×4 report with clinical depth. Our team has specialized training in genetic pathway analysis. This means that your results are reviewed through a lens that goes well beyond surface-level recommendations and can be used to make positive, proactive lifestyle changes.
Meet Marguerite Weston, MD, IFMCP
Dr. Weston Gets It. Because She Lived It.
She is double board-certified in Family and Sports Medicine. She is a former collegiate soccer player. She is a mother. Dr. Weston brings a rare combination of real-life experience and clinical depth to every patient she works with. She knows what it feels like to want more from your body, and she knows exactly how to find what’s standing in the way.
Her Approach is Proactive, Personalized & Preventive
Dr. Weston operates from one core conviction when it comes to genetic testing and functional medicine: the most powerful intervention is the one that never has to happen. She has earned Columbus Monthly’s Top Doctor recognition every year since 2019, is a trusted voice at the annual RTRX conference and leads a team of functional medicine specialists whose combined expertise spans nutrition science, gut health, hormone optimization and longevity medicine.
OUR PROVIDERS
Credentialed Experts, Collaborating For Your Wellness
Colleen Bush, RDN, LDN, IFNCP
Nutrition & Gut Health Specialist
Colleen builds personalized nutrition plans informed by your genetic results, accounting for how your body actually processes nutrients rather than relying on boilerplate dietary guidelines. She specializes in gut health optimization, autoimmune nutrition and sustainable lifestyle planning that fits real schedules.
Colleen builds personalized nutrition plans informed by your genetic results, accounting for how your body actually processes nutrients rather than relying on boilerplate dietary guidelines. She specializes in gut health optimization, autoimmune nutrition and sustainable lifestyle planning that fits real schedules.
Tricia Granchi, MSN, FNP-C
Functional Expert & CrossFit Athlete
An active CrossFit athlete with more than five years of competitive training, Tricia brings lived performance insight to functional medicine that many providers simply don’t have. She specializes in translating fitness and recovery markers from your genetic report into a movement and nutrition strategy you can implement immediately.
An active CrossFit athlete with more than five years of competitive training, Tricia brings lived performance insight to functional medicine that many providers simply don’t have. She specializes in translating fitness and recovery markers from your genetic report into a movement and nutrition strategy you can implement immediately.
Courtney Gilbert, MSPAS, PA-C
Women's Health & Hormones Specialist
Courtney helps patients understand how hormonal genetic patterns influence energy, mood and recovery. With more than a decade of experience in urogynecology and advanced training in functional medicine, she brings clinical depth to the hormone health sections of your Blueprint Report that directly support long-term performance and well-being.
Courtney helps patients understand how hormonal genetic patterns influence energy, mood and recovery. With more than a decade of experience in urogynecology and advanced training in functional medicine, she brings clinical depth to the hormone health sections of your Blueprint Report that directly support long-term performance and well-being.
Frequently Asked Questions About 3x4 Genetic Testing
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Your engagement includes the test kit, a comprehensive Blueprint Report analyzing 150+ genetic markers across 36 health domains and a 60-minute, one-on-one consultation with a credentialed care provider. During that appointment, your provider reviews your full report, answers your questions and builds a personalized action plan around your results.
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Your DNA doesn’t change, so your raw genetic markers stay the same throughout your life. That said, the interpretation of those markers can evolve as new research emerges. 3×4 Genetics updates its Blueprint methodology accordingly.
What does change is how you apply your results as your health goals shift over time.
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Ancestry tests tell you where you came from and general information regarding dispositions to specific conditions and other health risks. The 3×4 test tells you how your unique biology functions across metabolism, hormones, inflammation, brain health, fitness recovery and more.
The focus is entirely on actionable health insights. It is all about you and your DNA.
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No. 3×4 Genetic Testing is available to anyone. Your initial consultation is the starting point, and we’ll take it from there regardless of whether you’ve worked with us before.
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Most patients complete the full process within 5-6 weeks. This entails your first contact with our practice all the way to leaving your follow-up consultation. Lab processing makes up the lion’s share of that time, taking roughly three to four hours to complete.
Ready to Understand Your Health at the Biological Level?
Your genes have been there all along — telling you how you feel, how you recover and how you respond to everything you put your body through. The 3×4 Genetic Test, interpreted by a clinical team that knows what to do with the data, gives you a level of self-knowledge that changes how you approach your long-term health.
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