How To Inject Semaglutide At Home

Administering semaglutide at home requires careful attention to safety and precision. This step-by-step guide will help ensure you perform your injection properly to promote safe fat loss and minimize the risk of complications.

Important Notice:

This guide is not for Ozempic or Wegovy products. It is for compounded semaglutide injections only.

This page is intended for use by established patients who have been prescribed compounded semaglutide by a licensed provider and have received individualized instruction on administration. The compounded medication discussed here is not FDA-approved and is not intended to replace or substitute for FDA-approved GLP-1 therapies. Dosing, formulation and safety considerations may vary. Patients should never attempt to self-administer unless trained by a qualified professional and provided with specific instructions from their compounding pharmacy or provider.

Article updated 12/17/2025 to reflect recent FDA communications, regulatory clarifications and clinical context related to GLP-1 medications.

The Process Can Be Broken Down Into 5 Steps:

• Step 1: Gather Supplies & Wash Your Hands
• Step 2: Prepare The Injection Site
• Step 3: Prepare The Needle
• Step 4: Administer The Injection
• Step 5: Dispose Of The Needle

Once You’ve Gathered Your Materials:

• Wash your hands thoroughly with soap and warm water for at least 20 seconds. This step removes bacteria and prevents potential contamination during the injection process.
• Dry your hands with a clean towel or air dry to avoid introducing bacteria onto your supplies.

Step 2: Prepare The Injection Site

Selecting the right injection site is important for proper absorption and minimizing discomfort. Semaglutide is typically injected subcutaneously (just under the skin), most commonly in the following areas:

• Abdomen (our patients’ preferred area)
• Thighs
• Upper arms

Step 3: Prepare The Needle

Proper needle preparation is essential for safety and effective dosing. First, inspect the semaglutide vial for any discoloration or particles. The solution should be clear and free of any sediment.

How To Draw Up Your Prescribed Dose

• Remove the cap from the vial and clean the top with an alcohol wipe.
• Remove the safety cap from your needle.
• Prime the needle by inserting the needle into the vial, tilting the vial upside down and pulling back the plunger to draw a small amount of medication and pressing the plunger until a tiny drop appears at the needle tip.
• Reinsert the needle into the vial, title the vial upside again and pull back the plunger to draw the correct dose as prescribed by your healthcare professional.
• Double-check the dose before proceeding.

Step 4: Administer The Injection

Now that you’re ready to inject, follow these steps to ensure the procedure is smooth and painless:

• Pinch the skin at the cleaned injection site to create a small fold. This makes it easier to inject into the subcutaneous tissue, which lies just beneath the skin.
• Hold the syringe at a 90-degree angle for most areas of the body, or at a 45-degree angle if injecting into a thinner area of skin.
• Insert the needle quickly and smoothly into the skin to minimize discomfort. Avoid injecting into any veins or muscles — semaglutide should only be administered into subcutaneous tissue.
• Slowly depress the plunger to inject the medication. Take your time to ensure the full dose is delivered.
• Once the dose is administered, withdraw the needle carefully and immediately cover the site with a clean piece of gauze or cotton.
• Apply light pressure for a few seconds, but avoid rubbing the area, as this can cause irritation.

Proper Technique Is Necessary To Ensure Optimal Semaglutide Results

By working with a credentialed provider and following these steps carefully, you can administer semaglutide injections more effectively from the comfort of your home. Always consult your healthcare provider for any questions or concerns about your semaglutide therapy.

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